Impaired physical quality of life in patients with diastolic dysfunction associates more strongly with neurohumoral activation than with echocardiographic parameters: Quality of life in diastolic dysfunction.
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American Heart Journal
Issue: Volume 161(4), April 2011, p 797–804
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In DIAST-CHF, DD was prospectively identified and graded by an algorithm defined in the study protocol: Normal diastolic function (1 <= E/A, E/e' =1, E/A with Valsalva maneuver >=1), mild DD (E/A <1), moderate DD (1 <= E/A =10, S/D <1, E/A Valsalva =2 and 1 of the following: E/e’ >=10, S/D <1). . Conclusions: Physical dimensions of Quality of life are reduced in DD. Impaired Short Form 36-PF is only weakly associated with DD per se but rather seems to be contingent on the presence of elevated filling pressures. Biomarkers are more strongly and independently associated with SF-36-PF and may be more adequate surrogate markers of QoL in DD than echocardiographic measurements.
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Marcadores de disfunção diastólica ao ecocardiograma se correlacionam fracamente com índices obtidos por um questionário de qualidade de vida.
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O que será que estamos medindo ao ecocardiograma que não se correlaciona com a qualidade de vida, com o tratamento e mesmo com a redução da mortalidade?!?!?!?!?!?
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