Matrix Metalloproteinase-2 and -9 Levels in Patients with Dilated Ascending Aorta and Bicuspid Aortic Valve(Aqui) There were 54 patients with dilated ascending aorta (Group 1) and 58 patients with nondilated ascending aorta (group 2). The plasma levels of MMP-2 and MMP-9 were determined by ELISA. Results: The mean ascending aorta diameter was 4.49 ± 0.49 mm in group 1 and 3.51 ± 0.46 mm in group 2 (P < 0.001). There were no significant difference in gender, BSA, presence of hypertension, diabetes mellitus, hyperlipidemia, and smoking between the 2 groups. Nevertheless, no significant difference was observed in the levels of MMP-2 and MMP-9 between the 2 groups. A tese da aorta bivalvulada como doença da aorta é bem interessante. Mas o papel das estenoses e os gradientes resultantes não podem ser separados. Nesse estudo só casos leves de estenose foram incluídos. Desprezou-se o papel do Fenômeno de Bernoulli (abaixo) que certamente participa da dilatação.