https://www.frontiersin.org/articles/10.3389/fcvm.2018.00040/full
Stress echocardiography studies have shown that exercise PH (typically defined as systolic PAP > 60 mmHg) is associated with the future occurrence of symptoms in asymptomatic patients with at least moderate degenerative MR (44), cardiac events in patients with secondary MR (45), and cardiac events in asymptomatic patients with severe AS
