100 mil usos do IMT de Carótidas

https://doi.org/10.1161/CIRCULATIONAHA.120.046361

Conclusions:

The extent of intervention effects on cIMT progression predicted the degree of CVD risk reduction. This provides a missing link supporting the usefulness of cIMT progression as a surrogate marker for CVD risk in clinical trials.

What Is New?

• We analyzed data of 119 randomized, controlled trials that involved 100 667 patients and 12 038 incident cardiovascular disease events.
• We used a Bayesian meta-regression approach to evaluate progression of carotid intima-media thickness as a surrogate marker for cardiovascular events.
• Our analysis revealed a statistically significant association between treatment effects on progression of carotid intima-media thickness and treatment effects on cardiovascular disease risk.