Dia: 29 de março de 2022

https://www.mdpi.com/2077-0383/10/20/4628/htm

In conclusion, CIMT and carotid plaque reflects atherosclerosis burden in the whole arterial tree. Incidence and severity of CV risk factors (both traditional and non-traditional) have an impact on CIMT thickness and plaque burden, and more importantly, they are responsible for the rate of carotid atherosclerosis progression. CIMT and carotid plaque may play an additive role in scoring systems evaluating CV risk. Thus, it appears reasonable to combine established risk scores with CIMT and plaque imaging.

https://www.mdpi.com/2077-0383/10/20/4628/htm

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046361

• We analyzed data of 119 randomized, controlled trials that involved 100 667 patients and 12 038 incident cardiovascular disease events.
• We used a Bayesian meta-regression approach to evaluate progression of carotid intima-media thickness as a surrogate marker for cardiovascular events.
• Our analysis revealed a statistically significant association between treatment effects on progression of carotid intima-media thickness and treatment effects on cardiovascular disease risk.

Our study provides the key missing link supporting the usefulness of carotid intima-media thickness progression as a surrogate marker for cardiovascular disease risk in clinical trials.

Global and regional prevalence, burden, and risk factors for carotid atherosclerosis: a systematic review, meta-analysis, and modelling study

https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(20)30117-0/fulltext

Interpretation

A substantial global burden of carotid atherosclerosis exists. Effective strategies are needed for primary prevention and management of carotid atherosclerosis. High-quality epidemiological investigations on carotid atherosclerosis are needed to better address the global burden of carotid atherosclerosis at finer levels.

https://open.spotify.com/episode/1JAWgkErcTNNd1GiCWMUXX?si=RjT4UzlTT9e40TPZRGDdTQ

https://twitter.com/echotalk/status/1508488969553694720?s=21&t=0mR1CUcTNgaEZ6VJ_4wufg