Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046361
- We analyzed data of 119 randomized, controlled trials that involved 100 667 patients and 12 038 incident cardiovascular disease events.
- We used a Bayesian meta-regression approach to evaluate progression of carotid intima-media thickness as a surrogate marker for cardiovascular events.
- Our analysis revealed a statistically significant association between treatment effects on progression of carotid intima-media thickness and treatment effects on cardiovascular disease risk.
Our study provides the key missing link supporting the usefulness of carotid intima-media thickness progression as a surrogate marker for cardiovascular disease risk in clinical trials.