Chronic hydrodynamic disturbances experienced by the endothe- . lium can modulate adhesion molecule expression, plaque formation, . progression, and destabilization.28,42,43 Plaque size, composition and . geometric changes, along with adverse vessel remodelling alter both . endothelial shear stress, thus impinging upon the plaque itself44 and . influencing the biomechanical plaque stability.45 The proximity of . IFC-ACS lesions to coronary bifurcations—also—provides further . evidence linking shear stress alterations to the occurrence of IFC- . ACS,